Electrophysiological Effects of Neurotensin on Globus Pallidus Neurons of 6-Hydroxydopamine-Lesioned Rats

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Electrophysiological effects of neurotensin on globus pallidus neurons of 6-hydroxydopamine-lesioned rats.

The globus pallidus is a nucleus in the indirect pathway of the basal ganglia circuits. Neurotensin has been reported to play an important role in the central nervous system. Functional study revealed that systemic administration of neurotensin produced antiparkinsonian effects. The aim of the present study was to investigate the effects of neurotensin on the firing rate of globus pallidus neur...

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The globus pallidus plays a critical role in movement regulation. Morphological study has indicated that the globus pallidus receives neurotensinergic innervation from the striatum. The present study investigated the effects of activating neurotensin receptor in globus pallidus. In vivo single unit electrophysiological recordings showed that micro-pressure ejection of neurotensin into the globu...

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ژورنال

عنوان ژورنال: Neurosignals

سال: 2009

ISSN: 1424-862X,1424-8638

DOI: 10.1159/000199047